I develop for both front end and backend ASP.net web applications and I find myself using a slew of applications on a daily basis. Also, I have hobbies of game map creation using Source SDK Tools, Video Editing, and 3D modeling. Everytime I format my PC at home, I write out a laundry list of applications that I need to install.

 General Software

• 7-Zip - Open Source file archiver that handles Packing & unpacking: 7z, ZIP, GZIP, BZIP2 and TAR; Unpacking only: RAR, CAB, ISO, ARJ, LZH, CHM, MSI, WIM, Z, CPIO, RPM, DEB and NSIS
• Camtasia Studio - Easily record your screen to create training, demo, and presentation video.
• FireFox - Best browser on the planet.
• Live Mesh - Keeps some files and folders in sync on multiple computers.
  
• Métamorphose - Open Source to mass rename files and folders.
  
• Notepad++ - Free source code editor.
• Office - I do not use Office too often as I have my email going through gmail, but I still find myself using Outlook to at least sync my IMAP account.
  
• Virtual CloneDrive - Free virtual drive software.
• Windows Live Writer - Write and save blog posts. Intergrates nicely with BlogEngine.net.
  
• Xobni - Best Outlook plug-in to search and give stats about your inbox.
• Yahoo Messenger - The only IM I need to stay in touch with friends and family.
• Zune - Yes, I own a Zune.

Graphic Design/Game Development/3D Modeling

• Adobe Photoshop - Best image editor to date.
• Adobe Illustrator - Sometimes I need clean vector graphics.
• Pixologic ZBrush - Powerful 3D software to help sculpt detail into 3D geometry for games and film.
• Softimage XSI - 3D software for games, television and film.
• Valve Source SDK Tools - Game Developer toolkit to make and mod Valve Source games and Source Engine based games.

Development Software

• Adobe Dreamweaver - I make most of my CSS designs in Dreamweaver.
• Adobe Flash - Making rotating banners...etc. with actionscript.
  
• Adobe Flex - Software to help create Flash based Rich Internet Applications.
• Aptana Studio - A nice Open Source IDE for Javascript.
  
• VistaDB - The lightweight alternative to SQL Server.
  
• Visual Studio 2008 - Of course you know about this program.
• WinMerge - A nice Open Source comparison tool.
  

Games

• Call of Duty 4 - One of the nicest looking FPS to date.
• Counter Strike:Source - Oldie but goodie FPS Terroist vs Counter-Terrorist.
• Day of Defeat:Source - Similiar to CS:S but based on WWII.
  
• Team Fortress 2 - Change of the 'real-life' look FPS.
  
• Unreal Tournament 3 - Arcade FPS.